PCN74 Cost-Effectiveness of Radium-223 Dichloride (Radium-223) In Alsympca: A Cost-Effectiveness Analysis of Radium-223+Best Standard of Care (Bsoc) Compared With Placebo+Bsoc In Treatment of Castration-Resistant Prostate Cancer (Crpc) And Symptomatic Bone Metastases In Canada

Current models of sexual functioning imply an important role for both automatic and controlled appraisals. Accordingly, it can be hypothesized that erectile dysfunction may be due to the automatic activation of negative appraisals at the prospect of sexual intercourse. However, previous research showed that men with sexual dysfunction exhibited relatively strong automatic sex-positive instead of sex-negative associations. This study tested the robustness of this unexpected finding and, additionally, examined the hypothesis that perhaps more specific sex-failure versus sex-success associations are relevant in explaining sexual dysfunction and distress. Male urological patients (N = 70), varying in level of sexual functioning and distress, performed two Single-Target Implicit Association Tests (ST-IATs) to assess automatic associations of visual erotic stimuli with attributes representing affective valence (“liking”; positive versus negative) and sexual success versus sexual failure. Consistent with the earlier findings, the lower the scores on sexual functioning, the stronger the automatic sex-positive associations. This association was independent of explicit associations and most prominent in the younger age group. Automatic sex-positive and sex-failure associations showed independent relationships with sexual distress. The relationship between sexual distress and sex-failure associations is consistent with the view that automatic associations with failure may contribute to sexual distress

The inner craniodental anatomy of the Papio specimen U.W. 88-886 from the Early Pleistocene site of Malapa, Gauteng, South Africa

Cercopithecoids represent an essential component of the Plio-Pleistocene faunal assemblage. However, despite the abundance of the cercopithecoid fossil remains in African Plio-Pleistocene deposits, the chronological and geographic contexts from which the modern baboons (i.e. Papio hamadryas ssp.) emerged are still debated. The recently discovered Papio (hamadryas) angusticeps specimen (U.W. 88-886) from the Australopithecus sediba-bearing site of Malapa, Gauteng, South Africa, may represent the first modern baboon occurrence in the fossil record. Given the implication of U.W. 88-886 for the understanding of the papionin evolutionary history and the potential of internal craniodental structures for exploring evolutionary trends in fossil monkey taxa, we use X-ray microtomography to investigate the inner craniodental anatomy of this critical specimen. Our goal is to provide additional evidence to examine the origins of modern baboons. In particular,we explore (i) the tissue proportions and the dentine topographic distribution in dental roots and (ii) the endocranial organization. Consistent with the previous description and metrical analyses of its external cranial morphology, U.W. 88-886 shares internal craniodental anatomy similarities with Plio-Pleistocene and modern Papio, supporting its attribution to Papio (hamadryas) angusticeps. Interestingly, average dentine thickness and distribution in U.W. 88-886 fit more closely to the extinct Papio condition, while the sulcal pattern and relative dentine thickness are more like the extant Papio states. Besides providing additional evidence for characterizing South African fossil papionins, our study sheds new light on the polarity of inner craniodental features in the papionin lineage.Palaeontological Scientific Trust (PAST) Occitanie Region and the French Ministry of Higher Education and ResearchJNC201

Clinical and organizational quality indicators for the optimal management of stroke in adults: Scoping review protocol

ABSTRACT Introduction Clinical and organizational indicators have been developed to measure current stroke practices in different organizations. Although there is a broad range of indicators regarding the acute stroke phase, there is no synthesis of these indicators during this phase, and information is missing on how they have been tested, validated and integrated within organizations and clinical practice. The present article describes a scoping review protocol to identify clinical and organizational indicators conducive to the optimal management of acute ischemic stroke in adults. Method and analysis Our scoping review will be based on the methodological framework developed by Arskey and O’Malley (2005). Medline, CINHAL, Academic search complete and Cochrane Library databases will be used along with Google Scholar and Google to identify writings that meet the inclusion criteria. All scientific studies and grey litterature conducted and published since 2015, in French and English, dealing with clinical and organizational indicators for the management and optimal care of adults with acute ischemic stroke will be retained. Indicators will be classified based on the dimensions of care performance. Next, an advisory committee composed of clinical and scientific experts together with the partner patient will draw up a final list of indicators using the Delphi process. We expect this scoping review to identify the best clinical and organizational indicators for optimal acute stroke management, thus allowing for improved supervision of quality of care. Ethics and dissemination No ethical approval is required. Dissemination of the results will be made through scientific publications, poster and oral presentations

Reversed anisotropies and thermal contraction of FCC (110) surfaces

The observed anisotropies of surface vibrations for unreconstructed FCC metal (110) surfaces are often reversed from the "common sense" expectation. The source of these reversals is investigated by performing ab initio density functional theory calculations to obtain the surface force constant tensors for Ag(110), Cu(110) and Al(110). The most striking result is a large enhancement in the coupling between the first and third layers of the relaxed surface, which strongly reduces the amplitude of out-of-plane vibrations of atoms in the first layer. This also provides a simple explanation for the thermal contraction of interlayer distances. Both the anisotropies and the thermal contraction arise primarily as a result of the bond topology, with all three (110) surfaces showing similar behavior.Comment: 13 pages, in revtex format, plus 1 postscript figur

The Cold Big-Bang Cosmology as a Counter-example to Several Anthropic Arguments

A general Friedmann big-bang cosmology can be specified by fixing a half-dozen cosmological parameters such as the photon-to-baryon ratio Eta, the cosmological constant Lambda, the curvature scale R, and the amplitude Q of (assumed scale-invariant) primordial density fluctuations. There is currently no established theory as to why these parameters take the particular values we deduce from observations. This has led to proposed `anthropic' explanations for the observed value of each parameter, as the only value capable of generating a universe that can host intelligent life. In this paper, I explicitly show that the requirement that the universe generates sun-like stars with planets does not fix these parameters, by developing a class of cosmologies (based on the classical `cold big-bang' model) in which some or all of the cosmological parameters differ by orders of magnitude from the values they assume in the standard hot big-bang cosmology, without precluding in any obvious way the existence of intelligent life. I also give a careful discussion of the structure and context of anthropic arguments in cosmology, and point out some implications of the cold big-bang model's existence for anthropic arguments concerning specific parameters.Comment: 13 PRD-style pages, 2 postscript figures. Reference 26 corrected. Accepted to Phys. Rev.